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In Vitro BioAssays : Current status and future application for water management

State of the science report
Global water
Research coalition
Shane A. Snyder and Frederic D.L. Leusch
August 2018

11 février 2019

Life itself is based primarily upon organic chemistry, which has evolved over the earth’s history. Indeed, many organic chemicals of natural origin are necessary for human existence, likewise, many natural organic chemicals are toxic. In fact, what often determines the difference between health benefit and health adversity is the dose and homeostatis (equilibrium) among biological agonists and antagonists (substances that initiate or inhibit a biological response, respectively). This leads to the obvious principle that not all chemical mixtures are toxic nor are all chemical mixtures beneficial. What determines benefit or adverse outcome depends on the chemical composition, dose (exposure) andduration.